A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral provocation.

نویسندگان

  • Jae-Jeong Park
  • Sook Jung Yun
  • Jee-Bum Lee
  • Seong-Jin Kim
  • Young Ho Won
  • Seung-Chul Lee
چکیده

Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.

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عنوان ژورنال:
  • Annals of dermatology

دوره 22 1  شماره 

صفحات  -

تاریخ انتشار 2010